The twenty-first season of the American medical drama television series Grey's Anatomy returns as the story deepens when the new doctors step into leadership. Emotional fallout from the past season lingers, and big decisions shape the future of Grey Sloan. As the aftermath of a convenience store shooting brings chaos to Grey Sloan, Ben hits a wall with his new emergency preparedness plan. Meredith and Nick will return to Grey Sloan to treat a liver transplant patient. Jo and Link struggle with wedding planning as the day arrives, along with some visitors. Legacy characters and fresh faces continue to balance life, loss, and medicine.
S21E01
After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.
S21E02
Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support. Richard, Winston and Lucas spend the day outside of the hospital, and Blue deals with a relationship from his past. Levi meets the new hospital chaplain.
S21E03
Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant. Teddy offers Amelia a new opportunity, and Ben's interview doesn't go as planned. Meredith's secret causes tension with Richard.
S21E04
Mika struggles with a life-altering personal matter. Meanwhile, Bailey and Ben navigate their personal and professional roles, while Levi finds a connection in an unlikely place. Jo and Link get surprising news.
S21E05
During a high-stress day at Grey Sloan Memorial, the fates of a patient in critical condition and a helicopter-bound medical team hang in the balance. Teddy and Owen work on their marriage, while Bailey, Blue and Link treat a hospital employee.
S21E06
Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision.
S21E07
The doctors at Grey Sloan must put aside their emotions under intense circumstances. Levi asks James a shocking question that could impact their future.
S21E08
In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.
S21E09
The aftermath of the convenience store shooting brings chaos to Grey Sloan. Ben hits a wall with his new emergency preparedness plan. Romantic tensions surface for Owen, while Amelia and Winston disagree over the surgical plan for a young patient.
S21E10
Meredith and Nick return to Grey Sloan to treat a liver transplant patient. Meanwhile, Bailey hosts an intern retreat at her home, and Winston and Ben aid an unexpected crash victim.
S21E11
Following a difficult case, the team faces the complexities of medical ethics. Meanwhile, Bailey continues to navigate her working relationship with Ben, while a group of college students on a scavenger hunt causes chaos around the hospital.
S21E12
Meredith and Amelia prepare a funding proposal for their Alzheimer’s research. Meanwhile, Teddy and Owen hit a breaking point in their marriage, while Jules has an awkward encounter with Dr. Beltran.
S21E13
Amelia and Simone attempt to perform a high-stakes and groundbreaking brain surgery. Teddy and Bailey attend a medical conference and run into Dr. Cass Beckman. Meanwhile, Jo struggles with her irritation toward a younger OB-GYN.
S21E14
Bailey welcomes a renowned surgeon, whom she greatly admires, to Grey Sloan to help on a challenging case. Meanwhile, Teddy, Owen, Jules and Ben team up to save the life of a patient who has been impaled by an ice pick.
S21E15
A window washer’s platform crashes through a hospital window, testing the Grey Sloan team’s limits. Meanwhile, Blue and Simone clash over their living arrangements, and Lucas strives to impress Catherine while on her service.
S21E16
Amelia undertakes a high-risk brain surgery on a young patient, while Winston and Jules disagree over how to handle their trauma patient's family. Jo and Link struggle with wedding planning.
S21E17
Jo and Link's wedding day arrives, along with some visitors. Meanwhile, Teddy and Owen are met with a familiar face seeking treatment, and Lucas disagrees with Simone on how to approach a patient's worsened condition.
S21E18
While the interns are excited to transition to second-year residency, an ordinary day at Grey Sloan takes an unexpected turn when a medical emergency unfolds in the operating room, endangering lives inside the hospital.
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